Han van der Kolk
Euregio Laboratory Services, Maastricht, the Netherlands/ISME, Bern, Switzerland
Mitochondrial β-oxidation is essential in fat metabolism and can be monitored with acylcarnitine profiling in blood. To guarantee continuous energy supply during long-distance exercise, endurance horses oxidize considerable amounts of fat in the mitochondrion. In endurance races over 80 km, glycogen depletion is obvious in the equine slow twitch muscle fibres and as a consequence horses participating in an endurance race over 80 km rely almost fully on β-oxidation of fatty acids. Recent findings suggest that reduced bioavailability of carnitine in long-distance endurance horses might limit their performance. Growth hormone may be viewed as the primary anabolic hormone inducing a master fuel switch from carbohydrate utilization to lipolysis and lipid oxidation. Overtraining in young Standardbreds following 24-weeks of moderate-intensity training was associated with an increase in concentration peak number and an increased irregularity of nocturnal growth hormone pulsatility pattern. Four weeks of detraining did not lead to full recovery. Curriculum Vitae J.H. (Han) van der Kolk He studied veterinary medicine at the State University of Utrecht, the Netherlands. On August 28, 1987 he graduated in Veterinary Medicine and since the 1st of December, 1987 he had been working as a member of the staff of the Faculty of Veterinary Medicine, Utrecht University. On December 1, 2005, he was appointed associate professor in Equine Internal Medicine with endocrinology and muscle metabolism as area of research. From September 1, 2012 on he took a position as head of the section Equine Metabolic and Genetic Diseases of Euregio Laboratory Services, Maastricht, the Netherlands and was appointed director of the laboratory on January 1, 2015. Since September 1, 2014 he has been assigned as part-time staff member of the University of Bern, Switzerland regarding equine research with endocrinology and metabolism as focus area.